久久久久有精品国产免费,日韩一区二区三区一级电影,久久精品国产亚洲av伦理,久久久一区二区三区毛片

資訊中心NEWS CENTER

在發(fā)展中求生存，不斷完善，以良好信譽和科學(xué)的管理促進企業(yè)迅速發(fā)展

首頁-技術(shù)文章-CEM微波合成用于γ-Lactam的研究

企業(yè)新聞技術(shù)文章

CEM微波合成用于γ-Lactam的研究

更新時間：2012-06-29 點擊次數(shù)：2262

INTRODUCTION

One challenge facing peptide synthesis is the -lactam formation of arginine （Figure 1）. The formation of -lactam occurs when the internal nitrogen of the guanidine attacks the activated ester, irreversibly forming the lactam ring. This reaction is competitive with peptide-bond formation, greatly reducing the coupling efficiency of arginine.

Figure 1: γ-Lactam Formation

The goal of this study was to determine what effect microwave irradiation has on -lactam formation and how to optimize the microwave synthesis of arginine-containing peptides. As a test substrate, we selected the 1992 ABRF study peptide sequence. This sequence is known to suffer from Arg deletion due to -lactam formation.